In this class we will learn about how the process of DNA replication is regulated throughout the cell cycle and what happens when DNA replication goes awry. How does the cell know when and where to begin replicating its DNA? How does a cell prevent its DNA from being replicated more than once? How does damaged DNA cause the cell to arrest DNA replication until that damage has been repaired? And how is the duplication of the genome coordinated with other essential processes? We will examine both classical and current papers from the scientific literature to provide answers to these questions and to gain insights into how biologists have approached such problems. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

" In this class, students engage in independent research projects to probe various aspects of the physiology of the bacteriumĺĘPseudomonas aeruginosa PA14, an opportunistic pathogen isolated from the lungs of cystic fibrosis patients. Students use molecular genetics to examine survival in stationary phase, antibiotic resistance, phase variation, toxin production, and secondary metabolite production. Projects aim to discover the molecular basis for these processes using both classical and cutting-edge techniques. These include plasmid manipulation, genetic complementation, mutagenesis, PCR, DNA sequencing, enzyme assays, and gene expression studies. Instruction and practice in written and oral communication are also emphasized. WARNING NOTICE The experiments described in these materials are potentially hazardous and require a high level of safety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no responsibility, liability, or risk for the content or implementation of any of the material presented. Legal Notice "

Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.

The Introduction to Psychology course was developed through the Ohio Department of Higher Education OER Innovation Grant. This work was completed and the course was posted in September 2018. The course is part of the Ohio Transfer Module and is also named OSS015. For more information about credit transfer between Ohio colleges and universities please visit: www.ohiohighered.org/transfer.Team LeadVincent Granito                                    Lorain County Community CollegeContent ContributorsNicole Brandt                                       Columbus State Community CollegeLynne Gabriel                                      Lakeland Community CollegeJackie Sample                                     Central Ohio Technical CollegeLibrarianRachel Dilley                                       Columbus State Community CollegeReview TeamMelissa Beers                                      Ohio State UniversityBryan Gerber                                        Stark State College

 How to Use this GuideThis guide provides information and resources on teaching learning concepts in an Introduction to Psychology course. All resources are Open Access and can be downloaded or added to a Course Management System (LMS) via the hyperlinks.Although nature/nurture is not specifically addressed as a topic that falls under a Pillar, according to the TAG, these concepts can be applied across a number of required topics, such as Brain and Behavior, Lifespan Development, and Intelligence.   IntroductionThis section introduces students to the concepts of nature and nurture, and provides examples of psychological topics in which an understanding of the impact of both nature and nurture is crucial.  

"The mammalian brain easily outperforms any computer. It adapts and changes constantly. Most importantly, the brain enables us to continuously learn and remember. What are the molecular mechanisms that lead to learning and memory? What are the cellular roles that activity-regulated gene products play to implement changes in the brain?How do nerve cells, their connections (synapses), and brain circuits change over time to store information? We will discuss the molecular mechanisms of neuronal plasticity at the synaptic, cellular and circuit levels, especiallysynapse formation,synaptic growth and stabilization,synaptic transmission,axonal and dendritic outgrowth, andcircuit formationWe will learn about the roles of some activity-regulated genes as well as the tools and techniques employed in modern neuroscience. Our goal will be to understand molecular mechanisms the brain employs to accomplish learning and memory.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching."

Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts.

A millennial challenge in biology is to decipher how vast arrays of molecular interactions inside the cell work in concert to produce a cellular function. Systems biology, a new interdisciplinary field of science, brings together biologists and physicists to tackle this grand challenge through quantitative experiments and models. In this course, we will discuss the unifying principles that all organisms use to perform cellular functions. We will also discuss key challenges faced by a cell in both single and multi-cellular organisms. Finally, we will discuss how researchers in the field of synthetic biology are using the new knowledge gained from studying naturally-occurring biological systems to create artificial gene networks capable of performing new functions. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.