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Analysis of Biological Networks (BE.440), Fall 2004
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This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work will culminate in the preparation of a unique grant application in an area of biological networks.

Subject:
Biology
Chemistry
Life Science
Physical Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Essigmann, John
Sasisekharan, Ram
Date Added:
01/01/2004
Biochemistry and Pharmacology of Synaptic Transmission, Fall 2007
Conditional Remix & Share Permitted
CC BY-NC-SA
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Considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. Focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

Subject:
Chemistry
Physical Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Wurtman, Richard
Date Added:
01/01/2007
Biomolecular Kinetics and Cellular Dynamics (BE.420J), Fall 2004
Conditional Remix & Share Permitted
CC BY-NC-SA
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This subject deals primarily with kinetic and equilibrium mathematical models of biomolecular interactions, as well as the application of these quantitative analyses to biological problems across a wide range of levels of organization, from individual molecular interactions to populations of cells.

Subject:
Biology
Life Science
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Tidor, Bruce
Wittrup, Karl
Date Added:
01/01/2004
A Love-Hate Relationship: Cholesterol in Health and Disease, Fall 2005
Conditional Remix & Share Permitted
CC BY-NC-SA
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Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics.

Subject:
Health Sciences
Material Type:
Full Course
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Yesilaltay, Ayce
Date Added:
01/01/2005