This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.

Introduces representations, techniques, and architectures used to build applied systems and to account for intelligence from a computational point of view. Applications of rule chaining, heuristic search, constraint propagation, constrained search, inheritance, and other problem-solving paradigms. Applications of identification trees, neural nets, genetic algorithms, and other learning paradigms. Speculations on the contributions of human vision and language systems to human intelligence.

The focus of the course is on medical science and practice in the age of automation and the genome, both present and future. It includes an analysis of the computational needs of clinical medicine, a review systems and approaches that have been used to support those needs, and an examination of new technologies.

Microeconomics will ground you in - surprise - basic microeconomics-how markets function, how to think about allocating scarce resources among competing uses, what profit maximizing behavior means in industries with different numbers of competitors, how technology and trade reshapes the opportunities people face, and so on. We will apply economic ideas to understand current economic problems, including the housing bubble, the current unemployment situation (particularly for high school gradutes), how Google makes its money and why healthcare costs are rising so fast.

" The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month."

The provision of northern health care entails many unique challenges and circumstances that are rarely represented in mainstream health sciences education. This OpenEd Resource provides accessible content on health and health care from a northern perspective for the growing number of health professionals being educated in northern communities.

By examining the dynamic interplay between discourses of fiction and medicine, Novel Medicine demonstrates how fiction incorporated, created, and disseminated medical knowledge in China, beginning in the sixteenth century. Critical readings of fictional and medical texts provide a counterpoint to prevailing narratives that focus only on the “literati” aspects of the novel, showing that these texts were not merely read, but were used by a wide variety of readers for a range of purposes. The intersection of knowledge—fictional and real, elite and vernacular—illuminates the history of reading and daily life and challenges us to rethink the nature of Chinese literature.

This open access Nursing Skills textbook includes physical assessments routinely performed by entry-level registered nurses and basic nursing skills performed by licensed practical nurses. It is based on the Wisconsin Technical College System (WTCS) statewide nursing curriculum for the Nursing Skills course (543-102), the 2019 NCLEX-RN Test Plan, the 2020 NCLEX-PN Test Plan, and the Wisconsin Nurse Practice Act. Content and learning activities are included to encourage the student to engage in critical thinking and apply the nursing process while analyzing assessment findings. It also includes evidence-based clinical skills with related mathematical calculations and conversions.

Online learning activities are provided in each chapter using the free H5P software platform (https://h5p.org/). This textbook has also been uploaded to LibreTexts (https://libretexts.org/) for easy remixing by faculty.

The project is supported by a $2.5 million Open Resources for Nursing (Open RN) grant from the Department of Education and is licensed under CC-BY 4.0 creative commons license. This free book is available online and can also be downloaded in multiple formats for offline use. The online version is required for interaction with the adaptive learning activities included in each chapter.

Funded by the Department of Education, the Open RN site includes OER Nursing Textbooks with associated Virtual Reality scenarios.

Textbooks to be available:
Nursing Pharmacology (Fall 2020)
Nursing Skills (May 2021)
Nursing Fundamentals (Fall 2021)
Management & Professional Concepts (Summer 2022)
Mental Health & Community Concepts (Fall 2022)
Nursing Assistant (Fall 2022)

Virtual Reality Scenarios have been built based on the functionality using the Acadicus VR software platform but do not require VR equipment to be used. Media used in the simulations is also available on YouTube.

Parkinson's disease is a chronic, progressive, degenerative disease of the central nervous system that produces movement disorders and changes in executive functions, working memory, visuospatial functions, and internal control of attention in affected cognitive areas. It is named after James Parkinson (1755-1824), an English neurologist who studied the disease.

Experimental approaches to the study of the auditory periphery, presented through lectures by faculty and presentations of primary literature by students. Topics include: functional anatomy of the inner ear, transduction by hair cells, synaptic transmission, endocochlear potential, outer hair cells and their electromotility, responses of auditory nerve fibers, efferent control of cochlear function, inner-ear development, and damage and repair of hair-cell organs. Evaluations of students based on oral and written presentations, laboratory exercises, a final examination, and participation in discussions.

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Introducing public health ethics poses two special challenges. First, it is a relatively new field that combines public health and practical ethics. Its unfamiliarity requires considerable explanation, yet its scope and emergent qualities make delineation difficult. Moreover, while the early development of public health ethics occurred in a western context, its reach, like public health itself, has become global. A second challenge, then, is to articulate an approach specific enough to provide clear guidance yet sufficiently flexible and encompassing to adapt to global contexts. Broadly speaking, public health ethics helps guide practical decisions affecting population or community health based on scientific evidence and in accordance with accepted values and standards of right and wrong. In these ways, public health ethics builds on its parent disciplines of public health and ethics. This dual inheritance plays out in the definition the U.S. Centers for Disease Control and Prevention (CDC) offers of public health ethics: “A systematic process to clarify, prioritize, and justify possible courses of public health action based on ethical principles, values and beliefs of stakeholders, and scientific and other information” (CDC 2011). Public health ethics shares with other fields of practical and professional ethics both the general theories of ethics and a common store of ethical principles, values, and beliefs. It differs from these other fields largely in the nature of challenges that public health officials typically encounter and in the ethical frameworks it employs to address these challenges. Frameworks provide methodical approaches or procedures that tailor general ethical theories, principles, values, and beliefs to the specific ethical challenges that arise in a particular field. Although no framework is definitive, many are useful, and some are especially effective in particular contexts. This chapter will conclude by setting forth a straightforward, stepwise ethics framework that provides a tool for analyzing the cases in this volume and, more importantly, one that public health practitioners have found useful in a range of contexts. For a public health practitioner, knowing how to employ an ethics framework to address a range of ethical challenges in public health—a know-how that depends on practice—is the ultimate take-home message.

A framework of public hygiene and epidemiology is given. Human pathology related to water and sanitation is dealt with, as well as the relation between health and society and environment.

Radiation Oncology is a rapidly changing field with new advances being made daily. As a consequence, any textbook becomes out-of-date almost immediately after it is published. Thus, the WikiBook format is ideal for a textbook of radiation oncology, as updates can be made constantly as new information becomes available.

Subject presents a range of advanced topics in integrated logistics and supply chain management. Conducted in a lecture-discussion format, with participation of corporate executives as guest lecturers. Students prepare industry assessment analyses and make formal classroom presentations. Specific topics alternate from year to year, but basic content includes procurement strategies and strategic sourcing, dynamic pricing and revenue management tactics, mitigation of supply chain risk through supply contracts, strategic outsourcing of supply chain chain functions and operations, management and operation of third party logistics providers, and management of supply chain security.

This is an updated version of SEHRA. Version 4_2 allows users to add new patients to create their own scenarios. SEHRA (Sunshine EHR Academic), is an educational simulation of an electronic health records system using Access 2019 as the development platform. Piloted in December of 2019, SEHRA was successfully implemented in January of 2020, and became an essential part of SUNY Broome’s ability to take health science classes and clinicals online in March of 2020 in response to the COVID-19 pandemic. SEHRA continues to grow and is currently used in on-campus laboratories, remote courses, and for professional practice experience. As an ODC-ODbL, the Open Database License through Cornell’s Open Data Commons group, the database will stay free of charge and accessible to students and other developers through SUNY OER. Questions about SEHRA can be addressed to Sandra K. Wright, Professor Business Information Technology at SUNY Broome Community College, Binghamton, NY, wrightsk@sunybroome.edu.

Provides graduate students and fellows with techniques that enhance both validity and responsible conduct in scientific practice. Topics include study design, laboratory practice, treatment of data, human and animal research, intellectual property, preparation of proposals, research papers, posters, and oral presentations. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated as appropriate to the specific topic under discussion. Subject satisfies the training grant requirements of the NIH for education in the responsible conduct of research. This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic. This course also satisfies the training grant requirements of the NIH for education in the responsible conduct of research.

Welcome to the online coursebook for our Theories and Biological Basis of Addiction course. The material is designed to be read interactively or after downloading; while the embedded interactive exercises require internet connectivity, each can also be downloaded for offline work. These exercises are presented to help you test and apply what you are reading, challenge yourself, prepare for quizzes, and have a little fun along the way. The list of key terms at the end explains text highlighted in bold italics throughout the book—in the interactive mode you can click on a highlighted word to jump to its explanation in the key terms section. Use the back arrow to return to where you were reading.

Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of angiogenesis (formation of new blood vessels), blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, radiotherapy, chemotherapy, immunotherapy, hyperthermia, and photodynamic therapy of solid tumors.